Simulation of Genomic Recombination and the Influence of DNA Sequence Diversity on Cluster Formation and Detectability of Recombination: a Scientific Workflow Method

Jamal Alhiyafi; Shiyong Lu; Jeffrey L. Ram

doi:10.1504/IJCBDD.2009.027585

Simulation of Genomic Recombination and the Influence of DNA Sequence Diversity on Cluster Formation and Detectability of Recombination: a Scientific Workflow Method

Jamal Alhiyafi, Shiyong Lu, Jeffrey L. Ram

Kettering University

Research output: Contribution to journal › Article › peer-review

Abstract

The detection of recombination from DNA sequences is relevant to the understanding of evolutionary and molecular genetics. We developed a Recombination Simulation Scientific Workflow System (RSSWS) for simulating recombination and using GENECONV to test the effect of pairwise differences in a diverse population on the detectability of recombination. Decreases in recombination rate owing to pairwise differences resulted in population clusters analogous to sympatric speciation under specific conditions and decreases in detectability of recombination, a phenomenon that we call 'cryptic recombination'. This computational method demonstrated the value of scientific workflow methods for analysing a complex process and data driven problem.

Original language	American English
Journal	International Journal of Computational Biology and Drug Design
Volume	2
DOIs	https://doi.org/10.1504/IJCBDD.2009.027585
State	Published - Aug 3 2009

Keywords

DNA recombination
genomic recombination
DNA detection programmes
sympatric speciation
scientific workflow method

Disciplines

Genetics and Genomics

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10.1504/IJCBDD.2009.027585License: Unspecified

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Simulation of Genomic Recombination and the Influence of DNA Sequence Diversity on Cluster Formation and Detectability of Recombination: a Scientific Workflow Method. / Alhiyafi, Jamal; Lu, Shiyong; Ram, Jeffrey L.
In: International Journal of Computational Biology and Drug Design, Vol. 2, 03.08.2009.

Research output: Contribution to journal › Article › peer-review

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abstract = " The detection of recombination from DNA sequences is relevant to the understanding of evolutionary and molecular genetics. We developed a Recombination Simulation Scientific Workflow System (RSSWS) for simulating recombination and using GENECONV to test the effect of pairwise differences in a diverse population on the detectability of recombination. Decreases in recombination rate owing to pairwise differences resulted in population clusters analogous to sympatric speciation under specific conditions and decreases in detectability of recombination, a phenomenon that we call 'cryptic recombination'. This computational method demonstrated the value of scientific workflow methods for analysing a complex process and data driven problem. ",

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AB - The detection of recombination from DNA sequences is relevant to the understanding of evolutionary and molecular genetics. We developed a Recombination Simulation Scientific Workflow System (RSSWS) for simulating recombination and using GENECONV to test the effect of pairwise differences in a diverse population on the detectability of recombination. Decreases in recombination rate owing to pairwise differences resulted in population clusters analogous to sympatric speciation under specific conditions and decreases in detectability of recombination, a phenomenon that we call 'cryptic recombination'. This computational method demonstrated the value of scientific workflow methods for analysing a complex process and data driven problem.

KW - DNA recombination

KW - genomic recombination

KW - DNA detection programmes

KW - sympatric speciation

KW - scientific workflow method

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DO - 10.1504/IJCBDD.2009.027585

M3 - Article

VL - 2

JO - International Journal of Computational Biology and Drug Design

JF - International Journal of Computational Biology and Drug Design

ER -

Simulation of Genomic Recombination and the Influence of DNA Sequence Diversity on Cluster Formation and Detectability of Recombination: a Scientific Workflow Method

Abstract

Keywords

Disciplines

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