TY - JOUR
T1 - Design and Assessment of a Wrapped Cylindrical Ca‐P AZ31 Mg Alloy for Critical‐Size Ulna Defect Repair
AU - Atkinson, Patrick
AU - Smith, Montserrat Rabago
AU - White, Desiree
AU - Piersma, Tyler
AU - Gutierrez, Gloria
AU - Rossini, Gianny
AU - Desai, Sapna
AU - Wellinghoff, Stephen
AU - Yu, Hui
AU - Cheng, Xingguo
AU - Rabago-Smith, Montserrat
PY - 2011/11/21
Y1 - 2011/11/21
N2 - Recently, magnesium has been investigated as a promising bioresorbable orthopedic biomaterial. Its mechanical properties are very similar to natural bone, making it appropriate for load‐bearing orthopedic fracture repair applications. However, significant hurdles remain regarding the design of practical implants and methods to control degradation and enhance biocompatibility. Although attempts have been made to hinder magnesium's rapid corrosion via alloying and coating, these studies have used solid monoliths. In an effort to reduce the amount of alloy used for implantation in a shape that mimics cortical bone shape, this study used a thin sheet of Mg AZ31 which was rolled into hollow cylindrical scaffolds. The scaffold was coated with different amounts of Ca‐P; this implant demonstrated slowed corrosion in simulated body fluid (SBF) as well as enhanced biocompatibility for mesenchymal stem cells (MSC). In vivo implantation of magnesium alloy scaffold adjacent to the rat femur showed significant biointegration with further deposition of complex Mg‐Ca phosphates/carbonates typical of natural bone. Finally, the implant was placed in a critical‐size ulna defect in live rabbits, which lead to radiographic union and partial restoration of biomechanical strength in the defect. This study demonstrated that a thin sheet of coated Mg alloy that was spirally wrapped wound be a promising orthopedic biomaterial for bone repair.
AB - Recently, magnesium has been investigated as a promising bioresorbable orthopedic biomaterial. Its mechanical properties are very similar to natural bone, making it appropriate for load‐bearing orthopedic fracture repair applications. However, significant hurdles remain regarding the design of practical implants and methods to control degradation and enhance biocompatibility. Although attempts have been made to hinder magnesium's rapid corrosion via alloying and coating, these studies have used solid monoliths. In an effort to reduce the amount of alloy used for implantation in a shape that mimics cortical bone shape, this study used a thin sheet of Mg AZ31 which was rolled into hollow cylindrical scaffolds. The scaffold was coated with different amounts of Ca‐P; this implant demonstrated slowed corrosion in simulated body fluid (SBF) as well as enhanced biocompatibility for mesenchymal stem cells (MSC). In vivo implantation of magnesium alloy scaffold adjacent to the rat femur showed significant biointegration with further deposition of complex Mg‐Ca phosphates/carbonates typical of natural bone. Finally, the implant was placed in a critical‐size ulna defect in live rabbits, which lead to radiographic union and partial restoration of biomechanical strength in the defect. This study demonstrated that a thin sheet of coated Mg alloy that was spirally wrapped wound be a promising orthopedic biomaterial for bone repair.
KW - Magnesium
KW - Orthopedic
KW - Fracture
KW - Repair
KW - Scaffold
UR - https://digitalcommons.kettering.edu/mech_eng_facultypubs/60
UR - https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.b.31940
U2 - 10.1002/jbm.b.31940
DO - 10.1002/jbm.b.31940
M3 - Article
VL - 100B
JO - Journal of Biomedical Materials Research Part B: Applied Biomaterials
JF - Journal of Biomedical Materials Research Part B: Applied Biomaterials
ER -